Merck – Unlock High pH Stability in U/HPLC Columns: Discover the Ascentis® Express C18 pH+ Advantage

By Merck On Nov 4, 2025

Learn how Ascentis® Express columns deliver faster, cleaner separations with outstanding reliability in challenging high pH conditions.

Why Choose Ascentis® Express?

Exceptional stability at high pH (up to 12) and temperature (up to 60°C)
Fused-Core® technology for fast, efficient separations
Excellent LC-MS compatibility for sensitive applications
Reliable performance for acids, bases, neutrals, and zwitterions

Applications Covered in the Case Study

Drugs of Abuse Analysis – optimized amphetamine separation
Omeprazole Separation – stable high pH performance
Antidepressants – fast separation in under 3 minutes
Nicotine Analysis – enhanced retention at pH 10.15
Lidocaine Impurities – USP method modernization

Download the Case Study

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