Express Pharma

Session by Mallikarjun Reddy, Associate Director – Quality, Clearsynth

Analytical Development Conclave 2022 | 11th March 2022 | 1:30 PM - 6:30 PM IST | Virtual Conference

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In this video:
Session by Mallikarjun Reddy, Associate Director – Quality, Clearsynth

Topic: Dealing with challenges in testing and use of Stable Isotopic Labelled Standards

Key Highlights:
+ Labeled standards are preferred as Internal standards (ISTD) because they improve efficiency of bioassay or quantification method

+ The phytochemical properties of Label standards are almost similar to their unlabeled standards.

+ Deuterated and other isotope labelled internal standard have similar extraction recovery, ionisation response and matrix effect which improves the accuracy of quantification method

+ ISTD also reduces chromatography time, making an assay more robust by increasing the throughput and lowering rejection rates

+ Degree of labeling is very important while selecting an isotopic standard

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