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MetP Pharma nasal gel to be evaluated for potential to prevent HRV-A16 infection

The results of the study are expected at the end of October 2020

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MetP Pharma announced that its nasal gel Nascum-VIREX will be evaluated for its protective effect against viral infection. The aim of the study is to test the effect of acute dose apical exposure of Nascum-VIREX upon viral infection with Human Rhinovirus 16 (HRV-A16) using fully differentiated human nasal epithelial cells. Time points from zero to 96 hours are studied for the effect of the nasal gel on virus replication, toxicity markers, cilia and cytokines. The results of the study are expected at the end of October 2020.

“Nascum-VIREX is an oil-based nasal gel and a class 1 medical device according to Directive 2007/47/EC which has especially been developed to cover the nasal mucosa for several hours. The nasal gel is highly bio-adhesive and forms a physical barrier in the nasal cavity to significantly trap airborne particles by a mechanical effect. Moreover, through its positive charge, the gel binds negatively charged pathogens and viruses and thus shields the nasal cells from inhaled airborne particles through an electrostatic effect (Coulomb attraction),” informs a company release.

The nasal cavity is likely the major site of entry of pathogens like SARS-CoV-2 since most of the inhaled air enters the body through the nose. However, the virus must first overcome a 10–15 µm thick mucus layer in the nose which also contains numerous substances secreted by epithelial cells with inhibitory activity to inhaled pathogens and which is cleared and replenished by the basal epithelium many times per day. “Nascum-VIREX supports the mucus in capturing the virus before it infects the epithelium and the microscopic hair-like cilia move the gel-covered mucus in the back of the throat where it is then swallowed and destroyed by the acid in the stomach, or coughed up or sneezed out,” apprises the statement from the company.

The barrier properties of mucus are often diminished by pre-existing diseases, medications, life style and age. Also, the pathogen itself may cause the disruption of the ciliated epithelium or ciliary dyskinesia thus impairing mucociliary clearance which might facilitate viral infection. To prevent virus entry, it is of primary importance to increase the barrier function of the nose.

Dr Claudia Mattern, Chief Scientific Officer at MetP Pharma comments, “There is no guarantee that there will even be a COVID-19 vaccine and, if so, how long it will protect recipients, quite apart from the fact that it will take several years to develop a safe medication. Nascum-VIREX is immediately available to reduce or even prevent the virus entry at the mucous membrane of the nose thus helping the patient’s immune system fight the viral infection.”

Nascum-VIREX is an antiviral-modified version of Nascum-Plus gel.

Data from a preclinical study with the Nofer Institute of Occupational Medicine has demonstrated that the Nascum gel layer significantly protects against an increase in serum IgE and the BAL inflammation marker TNFα after exposure to industrial dust (2). In a clinical study with the Fraunhofer Institute for Toxicology and Experimental Medicine, the nasal gel significantly reduced Total Nasal Symptom Score (TNSS) after pollen challenge in an Allergen Challenge Chamber (3). In both studies, the nasal gel was well tolerated.

1 Comment
  1. ANJAN Routh says

    Nice product. It will to some extent reduce to spread COVID 19.In Kolkata one Green ENVIORNMENT company who are dealing with COVID 19 waste garbage, using antiseptic cream to prevent their staffs to attack from COVID 19.And hence till Dade none of their staffs attacked by COVID 19 within 4 months of their working with COVID 19 waste products.

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