Zydus Lifesciences (including its subsidiaries and affiliates), an innovation-driven global lifesciences company, launched REVAHALE (Revefenacin), India’s first once-daily nebulised Long-Acting Muscarinic Antagonist (LAMA) indicated for the maintenance treatment of Chronic Obstructive Pulmonary Disease (COPD).
REVAHALE is the first and only LAMA available in India that combines once-daily dosing with nebulised administration, offering a new treatment option for COPD patients who require nebulised therapy. Designed to provide sustained 24-hour bronchodilation with a single daily dose, REVAHALE addresses important challenges associated with inhaler-dependent therapies, particularly among elderly patients and those with severe respiratory impairment.
COPD remains a significant public health challenge in India and is a leading cause of morbidity and mortality. While inhaled bronchodilator therapies have transformed disease management, many patients continue to experience difficulties using handheld inhalers, cognitive limitations, severe breathlessness, or an inability to generate sufficient inspiratory effort for effective drug delivery.
REVAHALE has been developed to address these unmet needs through a convenient nebulised delivery platform that reduces dependence on inhalation technique and inspiratory flow. The therapy is compatible with standard jet nebulisers, providing flexibility and ease of use for patients and caregivers.
Revefenacin is designed to deliver sustained bronchodilation over 24 hours through once-daily administration. Clinical studies have demonstrated significant and sustained improvements in lung function in patients with moderate to very severe COPD, while maintaining a favourable safety profile. Its lung-selective design is intended to maximise bronchodilatory effects in the airways while minimising systemic exposure.
By combining once-daily administration, compatibility with standard jet nebulisers and sustained 24-hour bronchodilation, REVAHALE offers a differentiated maintenance treatment option in COPD care.