A separate analysis from the long-term follow-up extension study Longterms, showed that the rate of brain shrinkage in patients treated with Gilenya (fingolimod) remained similar throughout the six-year period, between 0.33 per cent and 0.46 per cent . This was broadly in the range you would expect to see in people without MS, while the typical rate of brain shrinkage experienced by patients with MS is approximately 0.5 per cent to 1.35 per cent per year,,,.
“Novartis is committed to generating data that advances science and clinical practice to improve the outcomes of patients. These new findings strengthen the link between brain shrinkage and long-term disability progression, supporting the significance of brain shrinkage for people with MS,” said Vasant Narasimhan, Global Head of Development at Novartis Pharmaceuticals. “The new data showing sustained low rates of brain shrinkage in Gilenya-treated patients with MS are reassuring because of the chronic debilitating nature of the disease.”
The rate of brain shrinkage for people with MS is around three to five times faster than people without the disease,,,, and what is lost cannot be recovered. Brain shrinkage can start early,,,, often goes unnoticed and is associated with a loss of physical and cognitive (i.e. memory) function for patients with MS.
Analyses of the pooled data from the phase III Freedoms core and extension studies showed that irrespective of treatment received brain shrinkage was associated with future long-term disability progression.
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EP News Bureau – Mumbai