Moderna says booster dose of its COVID-19 vaccine appears protective against Omicron

The company still plans to develop a vaccine specifically to protect against Omicron, which it hopes to advance into clinical trials early next year

Moderna Inc said today that a booster dose of its COVID-19 vaccine appeared to be protective against the fast-spreading Omicron variant in laboratory testing and that the current version of the vaccine would continue to be Moderna’s “first line of defense against Omicron.”

The vaccine maker said the decision to focus on the current vaccine, mRNA-1273, was driven in part by how quickly the recently discovered variant is spreading. The company still plans to develop a vaccine specifically to protect against Omicron, which it hopes to advance into clinical trials early next year.

“What we have available right now is 1273,” Dr Paul Burton, Chief Medical Officer, Moderna, said in an interview. “It’s highly effective, and it’s extremely safe. I think it will protect people through the coming holiday period and through these winter months, when we’re going to see the most severe pressure of Omicron.”

The company said a two-dose course of its vaccine generated low neutralising antibodies against the Omicron variant, but a 50 microgram booster dose increased neutralising antibodies against the variant 37 fold. A higher, 100 microgram booster dose of the same vaccine drove antibody levels even higher – more than 80 times pre-boost levels.

The data, which has not yet been peer-reviewed, tested blood from people who had received the vaccine against a pseudovirus engineered to resemble the Omicron variant. It is similar to data discussed last by top US infectious disease expert Anthony Fauci.

Burton said it would be up to governments and regulators to gauge whether they want the enhanced level of protection that a 100 microgram dose might confer.

The company said that the 100 microgram dose was generally safe and well-tolerated, although there was a trend toward slightly more frequent adverse reactions.

Moderna also tested the vaccine’s effectiveness compared to its prototype boosters that target multiple previous variants of concern, and said the results were similar.

The US regulators authorised the 50 microgram booster of Moderna’s vaccine in October. The first two shots of Moderna’s vaccine are both 100 micrograms.

Both the Moderna and the Pfizer/BioNTech vaccines have been linked to rare cases of heart inflammation, particularly in young men. Several studies have suggested that Moderna’s vaccine is likely to cause the heart inflammation at a higher rate.

Anthony FauciCovid 19 vaccineCOVID vaccine booster doseModernaModerna COVID vaccine
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