China’s Clover Biopharma said yesterday a booster shot of its COVID-19 vaccine candidate significantly increased antibody response against the Omicron coronavirus variant from levels seen after two primary shots.
A third dose of its vaccine candidate SCB-2019 resulted in a 19-fold increase in neutralising antibody levels against the Omicron BA.2 subvariant from pre-booster levels, Clover said in a filing to the Hong Kong stock exchange.
The booster shot also elicited a 12-fold rise in the neutralising antibody level against the BA.1 subvariant, the company said, citing preliminary analysis without providing detailed readings.
SCB-2019, which is backed by the Coalition for Epidemic Preparedness Innovation (CEPI), has yet to be approved for commercial use.
Data from a large clinical trial conducted before the spread of Omicron showed SCB-2019 was 67 per cent effective against symptomatic COVID-19 of any degree of severity and 79 per cent against the Delta variant.
Clover did not discuss cell-based responses elicited by the booster, another important part of human immune system different from antibody-based responses.
Clover is also testing a separate candidate SCB-2020S in an early-stage trial and working on a bivalent vaccine candidate targetting variants of concern including Omicron.
Antibody-based readings differ from a vaccine’s efficacy, a rate that reflects how well it could lower the risk of COVID disease or death.
Edits by EP News Bureau