Aptamer Group and BaseCure Therapeutics join hands for new targeted gene therapies

Optimer delivery vehicles could increase uptake of the siRNA therapy into the target cells

Aptamer Group, the developer of novel Optimer binders, has announced a new partnership with BaseCure Therapeutics for the development of Optimer-targeted gene therapies. BaseCure Therapeutics is a pre-clinical stage biotech company dedicated to the discovery and development of innovative siRNA-based medicines. Aptamer is working with BaseCure Therapeutics to identify Optimer binders that identify specific cell types that might be developed as potential delivery vehicles for siRNA uptake into target cells and tissues.

A company statement informed, “siRNA therapeutics form the largest portion of the rapidly developing gene therapy market, demonstrating excellent potential in the clinic. To date, there has been FDA approval of four siRNA treatments. However, despite these successes, targeting the therapeutic to the desired cell or organ within the body and further cellular internalisation to allow its gene silencing function remains a major challenge. This new partnership between Aptamer and BaseCure Therapeutics aims to support the future development of more targeted gene therapies.”

It added, “Optimer binders are oligonucleotide affinity ligands that can be used as antibody alternatives. Selected wholly in vitro, Optimers offer the potential to tune target affinity and half-life, and allow for site-directed payload conjugation for controlled Optimer: therapeutic ratios. Optimer binders can be combined with various payloads, from small molecule drugs to gene therapies, such as BaseCure Therapeutics’ siRNA. The ability to achieve Optimer-directed targeted delivery would offer exciting new therapeutic opportunities of siRNA-mediated gene knockdown in these target cells and tissues.”

Aptamer GroupBaseCure Therapeuticsgene therapiesOptimer binderspartnershipsiRNA therapeutics
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