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Waters unveils new line of calorimeters, new solid-core column chemistries


Glycan Analysis Kit has saved biopharmaceutical industry nearly four years of lab work

Waters Corporation unveiled its new line of differential scanning calorimeters reaffirming TA Instruments’ position as the technology and global leader in thermal analysis at the 2016 Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. Additionally, the company highlighted new CORTECS column chemistries and reported that its GlycoWorks RapiFluor-MS N-Glycan Kit has already saved biopharmaceutical laboratories industry-wide approximately four years of work based on sales in just its first year of availability.

The new line of Differential Scanning Calorimeters, the Discovery DSC 2500, DSC 250, and DSC 25 feature enhanced sensing technologies resulting in unprecedented performance in baseline flatness, sensitivity, resolution, and reproducibility.

At the core of every new Discovery DSC is the exclusive TA Fusion Cell, which incorporates design concepts that ‘fuse’ together features of the Q-Series and first generation Discovery DSC, patented Tzero technology, and new proprietary manufacturing processes. Additionally, an app-style user interface is standard with each new model and combined with powerful new TRIOS software, automated calibration and verification routines work seamlessly to dramatically improve laboratory work-flows and productivity.

The Discovery DSC measures the change in energy in a sample as the temperature is raised or lowered. It is used for a wide range of applications, including material science, pharmaceuticals, chemistry and studies of biomaterials. It excels in both research environments and production control processes.

The DSC 2500 comes standard with all options, which includes the all-new linear autosampler that allows for enhanced flexibility in assigning sample and reference pans to any combination of the available 54 positions. We believe that it is the only DSC on the market capable of making and storing heat capacity measurements in a single run.

The DSC 250 is a flexible and configurable research-grade DSC that includes Tzero technology, and is well-equipped to satisfy the most demanding researcher. The DSC 25 is a cost-effective, easy to use, general purpose DSC with performance superior to competitive research grade systems. It is ideal for research, teaching, and quality control laboratories that require a rugged, reliable, basic DSC.

Emphasising the impact of its innovations, Waters revealed that its GlycoWorks RapiFluor-MS N-Glycan Kit has already saved biopharma laboratories industry wide approximately four years of work in just its first year of availability. These calculations are based on purchases by all 15 top revenue generating pharma companies and 90 per cent of the top biopharma companies with glycoproteins in their pipeline.

Most biotherapeutic proteins available in the market today are glycoproteins. The heterogeneous glycan populations on these proteins are critical quality attributes that affect potency, stability, and therapeutic safety profiles. As a result, biopharma companies must provide detailed structural information pertaining to the glycans attached to their biotherapeutics when submitting new applications to regulatory authorities and on an ongoing basis throughout the manufacturing process. Waters estimates about 4.4 million released glycan analyses are performed per year, and that number is growing at double digit rates.

A ground-breaking technology for characterising glycoproteins, the GlycoWorks RapiFluor-MS N-Glycan Kit combined with Waters’ ACQUITY UPLC System, the ACQUITY UPLC FLR Detector and the ACQUITY QDa Detector, and enables scientists to analyse released N-glycans and achieve new levels of speed, sensitivity, simplicity while obtaining previously unattainable structural information.

Waters also added to its CORTECS Columns product family with the introduction of two new LC column chemistries. Built on Waters proven solid-core particle technology, the Waters CORTECS C8 and CORTECS Phenyl analytical columns are designed for scientists who need to expand their chromatographic separation space while maximising the speed, resolution and sensitivity of their small molecule HPLC, UHPLC or UPLC separations. Capable of operating at very high column efficiencies and low back pressures, the new columns give scientists additional selectivity choices and allow them to develop methods quickly, and generate more information with every analytical run. The CORTECS C8 and CORTECS Phenyl chemistries are available in two particle sizes, 1.6 and 2.7 micron, and are offered in a total of 50 unique column configurations.

CORTECS C8 Columns exhibit a lower hydrophobicity when compared to typical bonded C18 phases and are useful for separating strongly hydrophobic compounds. They are also ideal for chemists looking to transfer or scale compendial C8 HPLC methods to a more robust column technology.

CORTECS Phenyl Columns are an excellent alternative to typically bonded C18 phases, particularly for aromatic compounds, based on the unique selectivity provided by the phenyl bonded phase.

EP News BureauMumbai

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