Express Pharma

Indian scientists develop breakthrough dengue drug

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The project was jointly undertaken by DBT, ICGEB and Ranbaxy Research Laboratory and employed Ayurveda in devising the drug

In a breakthrough move that can help in the fight against dengue, a herbal medicine against it is claimed to have been developed by scientists in India, which accounts for 50 per cent of the global population estimated to be at risk from the disease.

Experts are now gearing up for the next step, which is to hold clinical trials and toxicity studies before seeking permission from the Ministry of Ayush and the Drug Controller General (India) (DCGI) for commercial production.

The project was jointly undertaken by the Department of Biotechnology (DBT), under the Ministry of Science and Technology, the International Centre for Genetic Engineering and Biotechnology (ICGEB) and Ranbaxy Research Laboratory (now owned by Sun Pharma), and employed Ayurveda in devising the drug.

“Using the knowledge of traditional Indian medicine, Ayurveda, we developed a systematic bioassay-guided screening approach to explore the indigenous herbal bio-resource to identify plants with pan-DENV (dengue virus) inhibitory activity.

“Results showed that the alcoholic extract of Cissampelos pariera Linn (Cipa extract) was a potent inhibitor of all four DENVs in cell-based assays, assessed in terms of viral NS1 antigen secretion using ELISA, as well as viral replication, based on plaque assays. Virus yield reduction assays showed that Cipa extract could decrease viral titers by an order of magnitude. The extract conferred statistically significant protection against DENV