Express Pharma
Home  »  Research  »  Lilly’s targeted RET drug shrinks tumours in lung cancer trial

Lilly’s targeted RET drug shrinks tumours in lung cancer trial

0 60

Lilly’s drug, now called selpercatinib, is intended for patients with rare RET abnormalities, which occur in about 2 per cent of non-small cell lung cancers

Eli Lilly and Co’s LOXO-292, a experimental cancer drug the company acquired in January as part of its $8 billion takeover of Loxo Oncology, shrank tumours in nearly 70 per cent of advanced lung cancer patients whose tumors carried specific abnormalities in the RET gene.

The results, at the World Lung Conference on Lung Cancer in Barcelona, will support Lilly’s application for US Food and Drug Administration approval later this year. “At the beginning of this year, we put a bet on Loxo,” Dr Daniel Skovronsky, Chief Scientific Officer, Lilly, said. “The result certainly validates that bet and exceeds what many people expected.”

Lilly’s drug, now called selpercatinib, is intended for patients with rare RET abnormalities, which occur in about 2 per cent of non-small cell lung cancers, some 10 to 20 per cent of papillary thyroid cancers and about 60 per cent of medullary thyroid cancers.

The study released included the first 105 patients with RET-fusion positive non-small cell lung cancers who had been previously treated with chemotherapy. Many had tried and failed to respond to several other treatments as well. As of the cut-off date of June 17, 2019, 68 per cent of treated patients had significant tumor shrinkage of 30 per cent or more. In 11 patients whose cancers had spread to the brain, 91 per cent saw significant tumour shrinkage of 30 per cent or more.

In a safety analysis of the whole study population of 531 individuals, nine patients, or 1.7 per cent, stopped the treatment because of drug-related side effects. The most common side effects were dry mouth, diarrhoea, high blood pressure, increased liver enzymes, fatigue, constipation and headache. The company also released preliminary data on 34 patients with RET-fusion positive lung cancer patients who had received no prior treatment. In this group, which has only been followed for about four months, 85 per cent saw significant tumour shrinkage.

Lilly plans to present data on patients with two kinds of thyroid cancers that carry RET alterations at the European Society for Medical Oncology meeting in Barcelona later this month. The company will file for FDA-approval of the drug in all three indications by the end of this year. Blueprint Medicines is also developing a lung cancer drug targeting RET alterations called BLU-677 and plans to file for FDA approval in the first quarter of 2020.

Reuters

Leave A Reply

Your email address will not be published.