Express Pharma

Ashland: From matrix to film coating, the full-service oral solid-dosage

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Ashland provides innovative solutions through a broad range of chemistries to meet the customers’ formulation needs

Ashland specialty ingredients offers an unparalleled range of products to meet the needs of the pharmaceutical and nutraceutical industries. Ashland’s products are based in both cellulosic and vinyl pyrrolidone polymer manufacturing. The company provides innovative solutions through a broad range of chemistries to meet the customers’ formulation needs.

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* Registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for Wacker

The global manufacturing sites operate in accordance with cGMP standards, ensuring consistent production of high-quality products. These products are supported by global research and development scientists and highly trained sales teams with expertise in oral solid-dosage formulation techniques and in current drug-delivery trends, including drug solubilisation and bioavailability enhancement.

Ashland is a full-service oral solid-dosage resource film coating and disintegration, as well as excipients for controlled release and drug solubilisation.

Ashland produces binders for wet granulation, dry granulation, direct compression and roller compaction.

With the exceptional range of binders produced by Ashland, one can be sure of finding the right one for formulation. Klucel hydroxypropylcellulose is the most versatile binder (different grades can be used in wet granulation, dry granulation or roller compaction) and is the first choice for many formulators.

Achieving a desired drug-release profile has long been based on trial and error involving blends of different molecular weights of particular polymers. Ashland offers high-quality cellulosic polymers to help take the guesswork out of the process. The need for blending to achieve a particular drug-release profile can be eliminated in some cases with custom-molecular weight grades of Benecel hypromellose for matrix tablets.

Effective tablet disintegration is necessary for drug dissolution and release. Polyplasdone crospovidone, a synthetic, cross-linked polymer, provides rapid disintegration and dissolution of oral solid dosage forms. Polyplasdone crospovidone combines rapid swelling and wicking (porosity and capillary action) mechanisms for tablet disintegration.

Ashland’s technical experts around the world can provide access to formulation and process-development technologies for solid dispersions (hot-melt extrusion and spray drying), granulation (fluid bed, high shear and hot-melt extrusion) and controlled release (release-profile prediction and simulation, melt extrusion, particle and pellet coating, drug layering and matrix tablets). Additional capabilities include compaction simulation, tablet production, and coating and stability studies. Ashland also has considerable expertise in characterisation of powder properties (flow, particle size, surface area and morphology).

Through the global network of technical service laboratories Ashland offers assistance with formulation development, problem solving and analytical support. The facilities are located in Wilmington, Del., US; Hyderabad, India; Istanbul, Turkey; São Paulo, Brazil; Shanghai, China; Mexico City, Mexico and Buenos Aires, Argentina

Ashland has recently launched a web-based film-coatings troubleshooting tool to enable formulators to quickly solve their toughest tablet-coating challenges. The new film-coating troubleshooting tool presents typical problems experienced during the coating process and insights that can help formulators resolve them. Ashland works closely with customers to enable them to choose the best coating for each formulation. It provides global technical assistance and deliver solutions to meet our customers’ product development needs.

Ashland has unveiled a completely refreshed pharma website. The new website is organised around Ashland’s key applications and products, making it more convenient for formulators to find the information they need and to be able to contact us directly with their questions.

For more information visit us at ashland.com/pharmaceutical or at CPHI India in Hall No. 1, Booth J38.

Contact Details:
Rohan Rastogi
Tel: +91 40 4474 8804
Email: [email protected]

Ninad Kelkar
Tel: +91 22 6148 4646
Email: [email protected]

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