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Himalaya study finds herbal immunomodulators effective as adjuvant treatment for COVID-19

The study states that adjuvant therapy with Septilin and Bresol along with SOC supports immunity and controls inflammation in COVID-19–positive patients and helps in the recovery of symptoms of post-COVID-19 illness

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The Himalaya Drug Company recently shared the results of the clinical study they commissioned to evaluate the role of their herbal products (Tab. Septilin and Tab. Bresol in combination) as an adjuvant treatment in mildly symptomatic and asymptomatic COVID-19–positive patients. The clinical trial was conducted under the supervision of Dr CR Jayanthi (MBBS, MD), Dean and Director of the Victoria Hospital (BMCRI – Bangalore Medical College and Research Institute), Bengaluru.

Septilin is a proprietary Ayurvedic formulation with immunomodulatory property and Bresol is recommended in the management of various respiratory conditions as it exhibits an anti-inflammatory effect because of its ability to downregulate proinflammatory cytokines.

“The study was conducted with a strong rationale that both Septilin and Bresol have been proven, in preclinical and clinical studies, to provide support and have a positive, multifaceted influence on immunity and respiratory functions. These products adhere to stringent quality parameters, which makes them ideal to be tested against COVID-19 without any concern whatsoever. The role of an immunomodulator and respiratory wellness support in combination (Tab. Septilin + Tab. Bresol) was evaluated as adjuvant therapy in a group of patients (group 1) who received standard of care (SOC) against another group that received only standard of care (group 2),” informed a statement for the company.

Dr Jayanthi said, “Patients treated with Septilin and Bresol along with SOC demonstrated a better trend of reduction of inflammatory cytokines (especially interleukin-6, lactate dehydrogenase, and neutrophil-lymphocyte ratio) as compared with patients who received SOC alone. Normalisation of D-dimer level was observed in all the subjects treated with Bresol and Septilin. This clinical trial has demonstrated that adding Septilin and Bresol as adjuvants may have additional long-term benefits in reducing inflammation and may prevent further injury and associated complications”.

Available literature on the COVID-19 pandemic shows a significant increase in the D-dimer level in COVID-19–positive patients and is associated with disease severity and mortality trends.

In the convalescence period of COVID-19 (after recovery from active COVID-19 infection), the combination of Septilin and Bresol was found to further benefit the individuals struggling to overcome a range of troubling residual symptoms. It was observed that the combination of Septilin and Bresol, brought about a statistically significant improvement in the energy levels, appetite, and concentration in patients in group 1 compared with those in group 2. Patients suffering from body pain, restricted joint movements, disturbed sleep, recurrent respiratory tract infection, and shortness of breath also demonstrated noteworthy improvement, compared with that at the beginning of the study.

“We believe that these findings may go a long way in helping patients who recover from COVID-19, lead healthier lives. After obtaining encouraging results from this study, Himalaya is further considering the expansion of such evaluation methods. It is expected that the addition of these products (which are already available in the market) to the standard treatment protocol, may support the “integrated holistic approach” of COVID-19 management,” said Dr Rajesh Kumawat, Head-Medical Services and Clinical Development, The Himalaya Drug Company.

Quality of life (QOL), which is a big concern in those suffering from COVID-19, was evaluated through a WHO questionnaire. Patients in group 1 reported feeling cheerful, relaxed, and active as compared to patients in group 2. A substantial improvement (statistically significant) was noticed in the overall QOL of patients in group 1. Fatigue, an intense concern in patients recovering from COVID-19, was assessed, and patients in group 1 demonstrated a significant improvement in the fatigue assessment score (FAS). All patients (100 per cent) in group 1 were completely devoid of fatigue after the treatment, while, 35 per cent of patients in group 2 continued to experience fatigue.

The statement informs, “This study has proved that adjuvant therapy with Septilin and Bresol along with SOC supports immunity and controls inflammation in COVID-19–positive patients. It also aids in the recovery of symptoms of “post-COVID-19 illness” and improves the overall well-being (including QOL and fatigue) of COVID-19 infected patients suffering from the post-COVID-19 syndrome.”

1 Comment
  1. hadil says

    thank you

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